Serotonin–dopamine reuptake inhibitor
CLASS OF DRUG
SDRI; DSRI; Dopamine-serotonin reuptake inhibitor; Serotonin and dopamine reuptake inhibitor; Dopamine and serotonin reuptake inhibitor; Serotonin-dopamine reuptake inhibitor
A serotonin–dopamine reuptake inhibitor (SDRI) is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitters serotonin and dopamine by blocking the actions of the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. This in turn leads to increased extracellular concentrations of serotonin and dopamine, and, therefore, an increase in serotonergic and dopaminergic neurotransmission.